51 days in Guatemala, Nicaragua & Panama Itinerary

51 days in Guatemala, Nicaragua & Panama Itinerary

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Route & dates

51 days in Guatemala, Nicaragua & Panama Itinerary

Start: Tulum, Mexico
+2
Drive + Fly + Drive:  16​h 45​min
1
Tikal National Park, Guatemala
— 1 night
Drive:  8​h 15​min
2
Lanquin, Guatemala
— 1 night
3
Antigua, Guatemala
— 9 nights
Drive:  2​h 30​min
4
San Lucas Toliman, Guatemala
— 1 night
+2
Drive + Fly + Drive:  9​h
5
Leon, Nicaragua
— 3 nights
6
Granada, Nicaragua
— 3 nights
Drive:  1​h 45​min
7
San Juan del Sur, Nicaragua
— 4 nights
Drive:  2​h 30​min
8
Isla de Ometepe, Nicaragua
— 4 nights
Fly:  11​h 15​min
9
Big Corn Island, Nicaragua
— 3 nights
Fly:  17​h 15​min
10
Panama City, Panama
— 5 nights
bus:  1​h 15​min
11
Colon, Panama
— 3 nights
bus + Fly:  2​h 30​min
12
Bocas Town, Panama
— 3 nights
Drive:  4​h 45​min
13
Boquete, Panama
— 4 nights
Drive + ferry:  3​h 45​min
14
Isla Bastimentos, Panama
— 2 nights
ferry + Drive:  1​h
15
Bluff Beach, Panama
— 1 night
+2
taxi + ferry + bus:  1​h 45​min
16
Changuinola, Panama
— 1 night
Fly + Drive:  16​h 45​min
End: Puerto Colombia, Colombia

1
night
Tikal National Park, Guatemala

Tikal National Park
Take a trip to Tikal National Park and discover an ancient city in the thick tropical jungle.
On the 13th (Wed), see the interesting displays at Centro de Conservacion e Investigaction.

Find out how to plan Tikal National Park trip without stress by asking Inspirock to help create an itinerary.

Tulum, Mexico to Tikal National Park is an approximately 17-hour combination of car and flight. The time zone changes from Eastern Standard Time to Central Standard Time, which is usually a -1 hour difference. You will have some time to spend on the 13th (Wed) before leaving for Lanquin.

Things to do in Tikal National Park

Museums
Find places to stay Nov 12 — 13:

1
night
Lanquin, Guatemala

Lanquin ©
San Agustín Lanquín, often referred to simply as Lanquín, is a municipality in the Guatemalan department of Alta Verapaz. Kick off your visit on the 14th (Thu): Head underground at Parque Nacional Grutas de Lanquin and then admire the sheer force of Monumento Natural Semuc Champey.

To see maps, photos, ratings, and other tourist information, read our Lanquin online journey planner .

You can drive from Tikal National Park to Lanquin in 8.5 hours. Other options are to do a combination of bus and shuttle; or take a bus. In November, daytime highs in Lanquin are 36°C, while nighttime lows are 25°C. Wrap up your sightseeing by early afternoon on the 14th (Thu) to allow time for the car ride to Antigua.

Things to do in Lanquin

Parks Nature

Side Trip

Parque Nacional Grutas de Lanquin
Find places to stay Nov 13 — 14:
Highlights from your plan
Monumento Natural Semuc Champey ©
Monumento Natural Semuc Champey

9
nights
Antigua, Guatemala

Antigua ©
The former capital of Guatemala and a World Heritage Site, Antigua retains its colonial charm and remains one of the most visited destinations in the country.
Explore the numerous day-trip ideas around Antigua: Guatemala City (La Aurora Zoo, Palacio Nacional, & more), Santo Tomas Church (in Chichicastenango) and Iximche (in Panajachel). There's still lots to do: contemplate the geological forces at Volcán Pacaya, stop by Nim Po't Centro de Textiles Tradicionales, explore the world behind art at Casa Santo Domingo Museums, and don't miss a visit to The Plaza Central Park.

To see photos, reviews, and other tourist information, go to the Antigua road trip planning site .

You can drive from Lanquin to Antigua in 5.5 hours. Other options are to take a shuttle; or take a bus. Expect slightly colder temperatures when traveling from Lanquin in November; daily highs in Antigua reach 27°C and lows reach 17°C. Wrap up your sightseeing on the 23rd (Sat) early enough to travel to San Lucas Toliman.

Things to do in Antigua

Historic Sites Museums Parks

Side Trips

Guatemala City, Santo Tomas Church, Iximche
Find places to stay Nov 14 — 23:
Highlights from your plan
Volcán Pacaya ©
Volcán Pacaya
Cerro de la Cruz ©
Cerro de la Cruz
Casa Santo Domingo Museums ©
Casa Santo Domingo Museums

1
night
San Lucas Toliman, Guatemala

San Lucas Toliman ©
San Lucas Tolimán is a municipality in the Sololá department of Guatemala. On the 24th (Sun), contemplate the geological forces at Lake Atitlan, then take in the spiritual surroundings of Colonial Church, and then examine the collection at Cojolya Museum and Store. On your second day here, get impressive views of Volcan Atitlan.

To see more things to do, traveler tips, and tourist information, you can read our San Lucas Toliman day trip site .

Traveling by car from Antigua to San Lucas Toliman takes 2.5 hours. In November, daily temperatures in San Lucas Toliman can reach 27°C, while at night they dip to 17°C. Wrap up your sightseeing by early afternoon on the 25th (Mon) to allow enough time to travel to Leon.

Things to do in San Lucas Toliman

Parks Nature Museums

Side Trips

Santiago Atitlan, Lake Atitlan
Find places to stay Nov 23 — 25:
Highlights from your plan
Lake Atitlan ©
Lake Atitlan
Volcan Atitlan ©
Volcan Atitlan
Cojolya Museum and Store ©
Cojolya Museum and Store

3
nights
Leon, Nicaragua

Leon ©
A cultured and storied city, Leon attracts guests from all over the world, drawn to the second city's style, thriving intellectual life, and liveliness.
Leon is known for nature, museums, historic sites, beaches, and shopping. Your plan includes some of its best attractions: contemplate the geological forces at Cerro Negro Volcano, take in the architecture and atmosphere at Catedral de la Asunción, get engrossed in the history at Museum of Legends and Traditions (Museo de Tradiciones y Leyendas), and contemplate the long history of Iglesia San Juan Bautista de Subtiava.

Make your Leon itinerary with Inspirock to find out what to see and where to go.

The Route module can help you plan travel from San Lucas Toliman to Leon. Expect somewhat warmer temperatures when traveling from San Lucas Toliman in November; daily highs in Leon reach 37°C and lows reach 27°C. Finish your sightseeing early on the 28th (Thu) to allow enough time to drive to Granada.

Things to do in Leon

Parks Nature Museums
Find places to stay Nov 25 — 28:
Highlights from your plan
Cerro Negro Volcano ©
Cerro Negro Volcano
Catedral de la Asunción ©
Catedral de la Asunción
Museo de Arte Fundacion Ortiz-Gurdian ©

3
nights
Granada, Nicaragua

Granada
The lakeside city of Granada has the look and feel of a historically important economic and political center, with grand colonial architecture, a unified look, and many cultural attractions.
You'll find plenty of places to visit near Granada: Apoyo (in La Laguna de Apoyo), Managua (Puerto Salvador Allende & Mercado Roberto Huembes) and Masaya Volcano (in Masaya). Next up on the itinerary: head off the coast to Islets of Granada, examine the collection at ChocoMuseo Granada, steep yourself in history at Palacio Episcopal, and pause for some serene contemplation at Catedral de Granada.

To find reviews, other places to visit, photos, and other tourist information, read Granada visit planner .

Traveling by car from Leon to Granada takes 2.5 hours. Alternatively, you can take a shuttle; or take a bus. Wrap up your sightseeing on the 1st (Sun) early enough to drive to San Juan del Sur.

Things to do in Granada

Parks Nature Historic Sites

Side Trips

Managua, Masaya
Find places to stay Nov 28 — Dec 1:
Highlights from your plan
Apoyo
Apoyo
Islets of Granada ©
Islets of Granada
Iglesia de La Merced ©
Iglesia de La Merced

4
nights
San Juan del Sur, Nicaragua

Set in a crescent-shaped bay, San Juan del Sur has become known as a popular surfing spot and coastal holiday destination for Nicaraguan families and international visitors alike.
San Juan del Sur is known for adventure, beaches, spas, wildlife, and outdoors. Your plan includes some of its best attractions: enjoy the sand and surf at La Flor Beach Natural Reserve, tour the pleasant surroundings at San Juan del Sur Beach, kick your exploration up a notch at some of the top local zipline courses and adventure parks, and have some family-friendly fun at Surf Ranch Skateboard Park.

To find where to stay, ratings, other places to visit, and other tourist information, you can read our San Juan del Sur trip itinerary planner .

Traveling by car from Granada to San Juan del Sur takes 2 hours. Alternatively, you can do a combination of shuttle and bus; or take a shuttle. Expect a daytime high around 34°C in December, and nighttime lows around 28°C. Cap off your sightseeing on the 5th (Thu) early enough to go by car to Isla de Ometepe.

Things to do in San Juan del Sur

Outdoors Parks Beaches
Find places to stay Dec 1 — 5:
Highlights from your plan
Zipline
La Flor Beach Natural Reserve ©
La Flor Beach Natural Reserve
San Juan del Sur Beach ©
San Juan del Sur Beach

4
nights
Isla de Ometepe, Nicaragua

Isla de Ometepe
Isla de Ometepe may be small in size, but it boasts two large volcanoes that dominate its landscape and influence the local lifestyle.
Isla de Ometepe is known for nature, beaches, museums, adventure, and outdoors. Your plan includes some of its best attractions: explore the activities along Laguna Charco Verde, examine the collection at Museo Ometepe, step off the mainland to explore Isla Ometepe, and find something for the whole family at Chico Largo Adventure.

For other places to visit, traveler tips, ratings, and tourist information, read Isla de Ometepe online itinerary planner .

Traveling by car from San Juan del Sur to Isla de Ometepe takes 2.5 hours. Cap off your sightseeing on the 9th (Mon) early enough to catch the flight to Big Corn Island.

Things to do in Isla de Ometepe

Parks Nature Theme Parks
Find places to stay Dec 4 — 9:
Highlights from your plan
Isla Ometepe
Isla Ometepe
Laguna Charco Verde ©
Laguna Charco Verde
Ojo de Agua ©
Ojo de Agua

3
nights
Big Corn Island, Nicaragua

Big Corn Island ©
The larger of the two islands, Big Corn Island offers a laid-back atmosphere and tropical island scenery.
Big Corn Island is known for wildlife, adventure, nature, and spas. Your plan includes some of its best attractions: see some colorful creatures with a scuba or snorkeling tour and head off the coast to nautilus corn island.

To see traveler tips, more things to do, and tourist information, read Big Corn Island travel route planner.

Traveling by flight from Isla de Ometepe to Big Corn Island takes 11.5 hours. Alternatively, you can ride a ferry; or do a combination of bus, taxi, and ferry. In December, daytime highs in Big Corn Island are 34°C, while nighttime lows are 28°C. On the 12th (Thu), you're off toPanama City.

Things to do in Big Corn Island

Parks Outdoors Wildlife
Find places to stay Dec 9 — 12:
Highlights from your plan
nautilus corn island ©
nautilus corn island
Scuba & Snorkeling

5
nights
Panama City, Panama

Panama City ©
Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Panama City is known for historic sites, shopping, museums, nature, and nightlife. Your plan includes some of its best attractions: make a trip to Panama Canal, appreciate the extensive heritage of Casco Viejo, wander the streets of Cinta Costera, and explore the activities along Gatun Lake.

For traveler tips, more things to do, where to stay, and other tourist information, go to the Panama City trip itinerary builder tool .

Use the Route module to find suitable travel options from Big Corn Island to Panama City. The time zone changes from Central Standard Time (CST) to Eastern Standard Time (EST), which is usually a 1 hour difference. In December, daily temperatures in Panama City can reach 36°C, while at night they dip to 28°C. Wrap up your sightseeing on the 17th (Tue) to allow time to take a bus to Colon.

Things to do in Panama City

Historic Sites Neighborhoods Parks
Find places to stay Dec 12 — 17:
Highlights from your plan
Panama Canal ©
Panama Canal
Amador Causeway (Calzada de Amador) ©

3
nights
Colon, Panama

Colon ©
Founded in the 1850s by Americans building the country's first railroad, Colon is now one of the largest duty-free ports in the world.
Get out of town with these interesting Colon side-trips: Portobelo (Safarick's Zoologico - Animal Rescue & Rehabilitation, Museo de La Real Aduana de Portobelo, & more). Next up on the itinerary: don't miss a visit to Gatun Locks, take in the spiritual surroundings of Iglesia de Cristo a Orillas del Mar, admire the landmark architecture of Mezquita de Colon, and contemplate the long history of Fort San Lorenzo.

To find photos, ratings, more things to do, and other tourist information, refer to the Colon trip builder .

Getting from Panama City to Colon by bus takes about 1.5 hours. Other options: drive. Cap off your sightseeing on the 20th (Fri) early enough to travel to Bocas Town.

Things to do in Colon

Historic Sites Outdoors Wildlife

Side Trip

Portobelo
Find places to stay Dec 17 — 20:
Highlights from your plan
Fort San Lorenzo ©
Fort San Lorenzo
Gatun Locks
Gatun Locks
Museo de La Real Aduana de Portobelo ©

3
nights
Bocas Town, Panama

The colorful and relaxed Bocas Town has a welcoming atmosphere, with the modestly sized urban area showcasing typical Caribbean clapboard houses and home to a mixed community from across the world.
Bocas Town is known for wildlife, beaches, outdoors, spas, and parks. Your plan includes some of its best attractions: look for all kinds of wild species at Wildlife Areas, enjoy the sand and surf at Boca del Drago, take in nature's colorful creations at Finca Los Monos Botanical Garden, and experience rural life at Up In The Hill.

To find photos, more things to do, ratings, and tourist information, refer to the Bocas Town trip planner .

You can do a combination of bus and flight from Colon to Bocas Town in 2.5 hours. Another option is to do a combination of bus and ferry. In December in Bocas Town, expect temperatures between 30°C during the day and 30°C at night. Wrap up your sightseeing on the 23rd (Mon) early enough to drive to Boquete.

Things to do in Bocas Town

Parks Outdoors Beaches

Side Trips

Up In The Hill, Finca Los Monos Botanical Garden
Find places to stay Dec 20 — 23:
Highlights from your plan
Scuba & Snorkeling
Finca Los Monos Botanical Garden ©
Finca Los Monos Botanical Garden
Boca del Drago ©
Boca del Drago

4
nights
Boquete, Panama

Boquete ©
Now known internationally for its fresh mountain air, year-round pleasant temperatures, and large community of North American expats, Boquete has changed rapidly since the start of the century, changing from a humble mountain town, into a humble mountain surrounded by gated communities and estates.
Boquete is known for nature, spas, trails, breweries & distilleries, and wildlife. Your plan includes some of its best attractions: savor a delicious cup with a coffee and tea tour, contemplate the geological forces at Volcan Baru National Park, shop like a local with Barbara Rabkin Art Studio, and trek along Sendero Los Quetzales (The Quetzales Trail).

To find traveler tips, reviews, photos, and more tourist information, use the Boquete online trip planner .

Drive from Bocas Town to Boquete in 5 hours. Wrap up your sightseeing on the 27th (Fri) to allow time to travel to Isla Bastimentos.

Things to do in Boquete

Parks Outdoors Tours
Find places to stay Dec 23 — 27:
Highlights from your plan
Volcan Baru National Park ©
Volcan Baru National Park
Boquete Bees ©
Boquete Bees

2
nights
Isla Bastimentos, Panama

Isla Bastimentos ©
Sitting fairly close to the mainland and just a short boat ride from Bocas del Toro International Airport, the well-connected but still preserved Isla Bastimentos offers access to a national park of protected rainforest and coastline, as well as an abundance of small, uninhabited islands dotted just offshore.
Start off your visit on the 28th (Sat): head off the coast to Isla Bastimentos and then tour the pleasant surroundings at Polo Beach. On the next day, kick back and relax at Wizard Beach and then tour the pleasant surroundings at Red Frog Beach.

To see ratings, other places to visit, maps, and other tourist information, you can read our Isla Bastimentos trip maker site .

Traveling by combination of car and ferry from Boquete to Isla Bastimentos takes 4 hours. Alternatively, you can do a combination of bus and ferry. December in Isla Bastimentos sees daily highs of 30°C and lows of 30°C at night. Cap off your sightseeing on the 29th (Sun) early enough to travel to Bluff Beach.

Things to do in Isla Bastimentos

Parks Outdoors Beaches
Find places to stay Dec 27 — 29:
Highlights from your plan
Red Frog Beach ©
Red Frog Beach
Wizard Beach ©
Wizard Beach

1
night
Bluff Beach, Panama

Bluff Beach ©
Kick off your visit on the 30th (Mon): look for all kinds of wild species at Bocas Butterfly Garden and then make a trip to Playa Bluff.

To find reviews, where to stay, other places to visit, and more tourist information, use the Bluff Beach trip planner .

Traveling by combination of ferry and car from Isla Bastimentos to Bluff Beach takes an hour. In December, daily temperatures in Bluff Beach can reach 30°C, while at night they dip to 30°C. Finish up your sightseeing early on the 30th (Mon) so you can travel to Changuinola.

Things to do in Bluff Beach

Parks Wildlife

Side Trip

Bocas Butterfly Garden
Find places to stay Dec 29 — 30:
Highlights from your plan
Playa Bluff ©
Playa Bluff

1
night
Changuinola, Panama

Changuinola ©
Changuinola is a city in the Bocas del Toro Province of Panama and seat city of the Changuinola District. Kick off your visit on the 31st (Tue): get outside with Aamvecona.

For more things to do and tourist information, you can read our Changuinola trip itinerary site .

Do a combination of taxi, ferry, and bus from Bluff Beach to Changuinola in 2 hours. Wrap up your sightseeing by early afternoon on the 31st (Tue) to allow enough time to travel back home.

Things to do in Changuinola

Outdoors
Find places to stay Dec 30 — 31:
Highlights from your plan
Aamvecona ©
Aamvecona

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